Oxalic acid excretion after intravenous ascorbic acid administration

Oxalic acid excretion after intravenous ascorbic acid administration.

Ascorbic acid is frequently administered intravenously by alternative health practitioners and, occasionally, by mainstream physicians. Intravenous administration can greatly increase the amount of ascorbic acid that reaches the circulation, potentially increasing the risk of oxalate crystallization in the urinary space. To investigate this possibility, we developed gas chromatography mass spec...

Oxalic acid excretion after methoxyflurane and halothane anaesthesia.

METttOXYFLURANE IS A general anaesthetic that has been implicated in the production of postoperative renal dysfunction. 1-6 The precise mechanism is unknown, but the finding of many oxalate crystals in the renal tubules, 5,6 and large amounts of oxalic acid in the urine of patients who develop renal failure after methoxyflurane anaesthesia s has suggested the possibility that oxalic acid may be...

Excretion of 35S-Tobias acid (2-naphthylamino, 1-sulphonic acid) by the rat after oral and intravenous administration.

Urinary and faecal excretion of radioactivity after either an intravenous or oral (1 mg/kg) dose of 35S-labelled Tobias acid (2-naphthylamino, 1-sulphonic acid), a dyestuff intermediate structurally similar to the powerful carcinogen 2-naphthylamine, was studied in rats. The Tobias acid was eliminated from the body within 24 hours of administration, almost exclusively through the urine. TLC-chr...

Oxalic acid

The metabolism of ascorbic acid-1-C14 and oxalic acid-C14 in the rat.

It is known that oxalic acid is a product of ascorbic acid metabolism in the guinea pig (1) and rat (2), and is formed in man from unidentified precursors (3). Oxalates are also of interest because of their occasional toxicity and unexplained deposition. Ascorbic, dehydroascorbic, and 2,3diketogulonic acids are known to give rise to oxalic and threonic acids in approximately quantitative yields...